Establishment of a 6-thioguanine (6-TG)-neo-resistant mutant human lymphoma cell line.
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چکیده
منابع مشابه
Line with Supersensitivity to 6-Thioguanine Characterization of a Hydroxyurea-resistant Human KB Cell
proteins. The Ml subunit is a Mr 170,000 protein with a binding site for substrates such as CDP (4, 5). M2 (Mr 88,000) contains a tyrosyl free radical, a unique protein-bound organic free radical, and non heme iron. The iron and the tyrosyl groups are essential for the RR enzyme activity. HU is known to target on M2, interfering with the free radical of M2 and thereby inactivating RR activity (...
متن کاملCharacterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine.
Hydroxyurea (HU) is currently used in the clinic for the treatment of chronic myelogenous leukemia, head and neck carcinoma, and sarcoma. One of its drawbacks, however, is the development of HU resistance. To study this problem, we developed a HU-resistant human KB cell line which exhibits a 15-fold resistance to HU. The characterization of this HU-resistant phenotype revealed a gene amplificat...
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Human herpesvirus 6 (HHV-6) DNA has been detected in several human lymphoproliferative disorders. We report a case of HHV-6-infected Burkitt's lymphoma, from which a cell line, designated Katata, has been established. Katata cells had an immature B-cell phenotype with an L3 morphology and carried a t(8;14)(q24;q32) chromosomal abnormality. The HHV-6 DNA sequences were detected in both the patie...
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متن کامل6-Thioguanine treatment in inflammatory bowel disease: a critical appraisal by a European 6-TG working party.
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004, European experts applying 6-TG further on in IBD patients presented data on safety and efficacy of 6-TG. After thorough evaluation of its risk...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 1988
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.11.346